If you’re visiting Panama and want to make the most of your time in the capital, this guide is for you. Whether you’re into history, food, nature, or modern city life, here’s a full itinerary of what to do in Panama City in just three intense and unforgettable days before your Caribbean crossing.
Day 1: Get to Know the City’s History and Heart
Morning Start with a visit to the Panama Canal – Miraflores Locks, the most iconic site in the country. To see the massive ships in motion, we recommend arriving early (8:00 AM) or late in the afternoon (after 3:00 PM). This is the perfect introduction to the country that connects the world.
Afternoon Head to Casco Viejo, the historic old town. Walk its cobblestone streets, admire colonial buildings, and stop for a coffee at a local café. Many travelers use this time to meet their fellow adventurers before their trip to Colombia.
Evening Finish the day with sunset drinks on a rooftop bar overlooking the city. Tantalo and CasaCasco are two popular spots for both locals and travelers to see the skyline light up before trading the city lights for the stars of Guna Yala.
Day 2: Nature, Culture, and the Gateway to the Caribbean
Morning Explore Metropolitan Natural Park, a tropical forest within the city limits. Hike to the top for panoramic views and a chance to spot toucans or monkeys. It is a great way to warm up for the island life that awaits you.
Afternoon Visit the Biomuseo, a colorful museum designed by Frank Gehry that explains Panama’s biodiversity. It’s located along the Amador Causeway, a beautiful strip that connects small islands to the mainland—a perfect preview of the archipelago scenery you will experience on our 4-day boat journey.
Evening Eat at a seafood market like Mercado de Mariscos for fresh ceviche. This is a must-do for anyone traveling from Panama to Colombia, as the flavors of the Pacific and the Caribbean start to blend here.
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Day 3: The Most Iconic Route Between Panama and Colombia
Morning: The Ultimate Day Trip or Final Preparation Instead of a city tour, many travelers use this day to prepare for the best part of their South American journey. If you are traveling between Panama and Colombia, the San Blas crossing is the most authentic way to connect both countries. Our 4-day trip departs near the city, taking you through 365 islands of the Guna Yala territory.
Afternoon: City Markets and Local Neighborhoods Walk through Avenida Central and visit markets like Mercado de Abastos for a taste of everyday life. If you’re heading to Colombia next, this is a great place to pick up some last-minute tropical snacks for the boat.
Evening: Farewell to the City Return to Casco Viejo for a final dinner or take a night walk along the Cinta Costera for views of the lit-up skyline. This is your last night of “city life” before entering the remote and beautiful San Blas archipelago.
Final Tip: Why Island Hopping is the Way to Go
Three days in Panama City can feel short, but it’s the perfect amount of time to get ready for your Caribbean escape. If you’re traveling between Colombia and Panama, don’t just take a flight. The boat trip through San Blas is a life-changing experience that connects the two countries while immersing you in the Guna culture and pristine nature.
Planning to continue your adventure after the city? Explore the San Blas Islands and add the perfect Caribbean escape to your Panama or Colombia itinerary.
